Ultimate Guide To NAD+ & NMN

 

Have you ever wondered how children have so much energy?

We all have and here’s a scientific basis behind children having more energy than their adult counterparts – higher levels of NAD+.

By the time you turn 80, your NAD levels have dropped to as low as 1% compared to your youth.

NAD depletion plays an enormous role in aging.

Your cells don’t produce energy as effectively which leads to age-related deterioration.

To put it simply (and rather bluntly): without NAD, you die.

Would you like to age healthily rather than experiencing the horrendous complications most people of an older age are now experiencing in today’s environment?

Then you must maintain optimum levels for you to age healthily.

 

Graph Showing Decline In NAD+ Levels

What Is NAD+?

 

First discovered in 1906, Nicotinamide Adenine Dinucleotide is made naturally in our bodies from NMN & Vitamin B3 and is found in every cell of your body.

NAD is an oxidising agent (accepts electrons from other molecules and reduces) known as coenzyme 1 (the most important) because it powers many essential chemical reactions.

It has two core functions:

  1. Turn your nutrients into energy
  2. Helping protein regulate other cellular functions

For you to transport energy into your cells, you require NAD to help power them; it powers our mitochondria which are “the batteries of your cells”.

Mitochondria turn your food into energy which is crucial for our survival.

 

What Is NMN?

 

Nicotinamide Mononucleotide is a naturally occurring, safe vitamin B3 metabolite found in our body derived from ribose and nicotinamide.

NMN is a NAD precursor and is metabolised to NAD+ in our cells.

NMN & NAD are essential in producing ATP (energy) via the Krebs Energy Cycle (citric acid cycle) which is a series of chemical reactions used by every aerobic organism to release energy from carbs, fats and proteins that produces the CO2 you breathe out – also producing 2 ATP & 6 NADH.

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How Much NAD+ / NMN Can I Take?

 

Harvard Professor, David Sinclair, recommends in his book Why We Age - and Why We Don’t Have To that people should take 1 gram of NMN once daily.

Here at BioTech Life Sciences, we would recommend you build your tolerance up gradually with 250mg dosages (our packaging includes 250mg spoons) once a day and increase your dosage every 2-3 day’s until you hit a threshold of 1g.

The reason for this is that NAD+ & NMN affect people differently and some may have more or less than others naturally – an initial 1,000 gram dosage may be too much for certain individuals to begin with.

It is best to start off small and build your dosage up over the course of a week or two to get accustomed.

Unfortunately, many companies will recommend their customers to dose 1,000mg straight away so that the customer uses their NAD+ or NMN and have to buy from them again.

 

What Is The Difference Between NAD+ & NMN?

 

The main difference between both Nicotinamide Adenine Dinucleotide & Nicotinamide Mononucleotide (NMN) is that NMN is a NAD+ precursor (comes before NAD+) but you can’t have one without the other.

They both contain the same nucleotide of nicotinamide, but they differ in the other nucleotide with NMN containing ribose and NAD containing adenine - the NMN molecule is smaller in size than the NAD+ molecule.

NMN has shown to be slightly more bioavailable (absorbed into the bloodstream) than NAD+ with NMN having more noticeable effects physically and NAD+ promoting more mental benefits.

A study showed that the absorption factor of NMN from the gut into the blood circulation starts within 2-3 minutes and completely absorbed into the tissue within 15 minutes. After it has been converted, it is stored as NAD+ immediately in the tissues such as the liver, skeletal muscle and cortex.

 

Risks & Dangers of NAD+ & NMN

 

Due to NAD+ being discovered over 100 year’s ago (1906), it has a large volume of research behind it.

Studies carried out on Japanese men showed dosages of 500mg to be safe and a long-term study that lasted a year didn't show any adverse effects or toxicity.

The common assumption amongst people who hear about NAD or NMN is that because they haven’t heard of it before, it must be new – nothing could be further from the truth.

In fact, vitamin C was discovered after it.

As with any supplement available today, there are the mild symptoms that a very small proportion of the population will experience from taking a particular supplement such as:

  • Momentary digestion trouble
  • Stomach cramps
  • Nausea

This can be attributed more so to the individual rather than the supplement and is expected with any supplement or food for that matter – we are not all built the same.

 

Where Should You Buy Your NAD+ / NMN?

 

Unfortunately, there are more bad products than good for NAD+ & NMN.

Many companies have decided to put their profit first and the quality of their product second to the detriment of the customer.

Unless you’re buying from a company that offers NAD+ or NMN in powder form, which is to be taken sublingually in sealed packaging, the bioavailability of what you are getting is significantly reduced (up to 50% - 60%).

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Why You Must Take NMN / NAD+ Sublingually

 

Many supplements for NAD & NMN are in pill or capsule form which has low bioavailability (not much is absorbed into your body = waste of money & ineffective).

For example, when you take a NAD precursors such as Nicotinamide Mononucleotide as a capsule or pill, it is primarily digested in the gastrointestinal tract and processed by the liver; when you take it sublingually (under the tongue), it can bypass the stomach and liver.

By taking it sublingually, studies show you can increase the absorption rate by 3x – 10x more than by capsules.

The only method that has a higher absorption factor is via an IV which is also extremely expensive and not viable for 99% of people.

 

Should You Take Anything Else With NAD+ & NMN?

 

On its own, NAD+ / NMN is more than enough, but if you would like to optimise your daily regimen or stack further then you can look at including other supplements such as:

  • Resveratrol
  • B9 Methyl folate (not folic)
  • B12 Methylcobalamin (not cyano or adenosylcobalamin)

Of course, a healthy diet consisting of whole-foods (preferably organic) alongside a regular exercise routine will help too.

*For foods high in NAD+, you can see our list further down this article.

 

Benefits of NAD+ & NMN

 

You probably started researching NAD+ / NMN after hearing about the fantastic benefits people can experience from taking it over just a short period of time.

There is a reason people have labelled it a “miracle vitamin” or “fountain of youth pill”.

People have been experiencing a plethora of benefits, both physical and mentally.

 

Physical Benefits NAD+ & NMN May Have:

 

  • Enhanced Lean Muscle
  • Boost Strength & Muscle Mass
  • Helps Support Cartilage & Joint Function
  • Optimise Performance by Reducing Tiredness & Fatigue
  • Supports Energy Production
  • Supports Bone Health
  • Longevity Gene Activation
  • Stimulate Metabolic Process
  • Positive Anti-Aging Effects
  • Supports The Immune System
  • Promotes Healthy Inflammatory Response In The Body & may Reduce Key Inflammation-Promoting Enzymes
  • Maintain Healthy Thyroid Hormone Levels
  • Boosts Energy & Energises Cells
  • Defends Against Free Radicals
  • Promotes DNA Repair
  • Maintains Healthy Mitochondria

 

Mental Benefits NAD+ & NMN May Have:

 

  • Supports Mood
  • Reduces Stress & Frustration
  • Promotes Relaxation
  • Helps Maintain the Sleep/Wake Cycle
  • Greater Mental Clarity
  • Maintain Mental Performance During Training
  • Assist with Cortisol Management
  • Helps to Maintain Memory & Cognitive Abilities
  • Helps Restore Mental Alertness

 

Difference Between NR & NMN

 

Nicotinamide Riboside (NR) is a smaller molecule than NAD+ & NMN and it acts as both a NAD precursor and NMN precursor.

NMN is NR but with an extra (crucial) molecule attached called a phosphate (charged ion that contains the mineral phosphorus).

Both NR & NMN are NAD precursors and they have both shown to benefit the health of elderly mice with neither of them showing negative health effects even in long-term mouse experiments.

 

How To Increase NAD+ Levels Naturally

 

Aside from supplementing with NAD+, you can naturally increase your levels (in tiny amounts) from:

  • Exercise
  • Following a Ketogenic Diet
  • Fasting

If you are looking to increase your NAD+ through your food intake, then you should look at including the following foods in your daily diet:

  • Milk – research has shown that cow’s milk is a good source of Nicotinamide Riboside. 1 litre of cow’s milk contains roughly 3.9 umol of NAD+.
  • Fish – tuna contains 20.5mg, salmon contains 10.1mg
  • Mushrooms – include these into your salads or as a side dish into your meals (especially crimini mushrooms contain 3.3mg of NAD+)
  • Green Vegetables – proven to contain NAD+ with peas & asparagus containing 3.2mg & 2mg
  • Chicken – contains 9.1mg

 

Unhealthy Foods Which Contain NAD+

 

  • Yeast – Helping dough rise whilst rising your NAD+ levels, the stuff used in bread & bakery products contains NR
  • *Beer – some of you will be happy to see that your favourite brew is a source of NAD+ due to the yeast required to make it having NAD+ in it, but unfortunately, it actually reduces your NAD+ levels because the metabolism of alcohol requires the conversion of NAD+ to NADH which depletes NAD+. A consequence of this conversion is a fatty liver, hypoglycaemia and cirrhosis

 

FAQs

 

What Should I Buy, NAD+ or NMN supplement?

The main difference between NMN or NAD simply comes down to the research carried out for each individual compound.

Harvard Professor, David Sinclair, has alluded to activators stimulating different Sirtuins.

There has been some research which shows NMN benefits the body with NAD benefitting the brain.

We recommend trying both and deciding which product has the best effects for you.

How Safe Are NAD+ / NMN Supplements?

There have been human trials as well as multiple studies on animals which show it to be extremely safe for human consumption.

How Pure Is Your Product?

Our NAD+ & NMN powder is >99% pure and we don’t add any fillers, extra ingredients or toxic chemicals like our competitors. No dairy, gluten, wheat, soy, artificial colors, preservatives, non-GMO and suitable for vegans.

Should I Take Capsule / Pills For NAD+ / NMN?

If you want high bioavailability and to have NAD+ / NMN that benefits your body then no – always go for sublingual powder-form.

How Much Should I Take?

Test with just one 250mg dosage and build up by dosage each day until you reach a maximum of 1,000mg over 4 dosages.

How Do You Test?

We are 3rd party tested and we choose to go through multiple stages of testing that isn’t required to achieve our own internal standards as well as our customers.

Where Should I Store My NAD+ / NMN?

Our NAD+ / NMN is of the highest-quality currently available so it will last longer than most brands, but we always recommend to keep it in a cool, dry place away from sunlight.

 

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