NAMPT - Mediated NAD+ Biosynthesis essential for vision in mice

Vision depends on photoreceptors in our eye for light transduction.  Photoreceptor death is the endpoint of many blinding diseases.

Photoreceptors make up a significant portion of the neurosensory retina, one of the most metabolically active tissues in the body (, , ). 

In addition, these receptors have a tremendous metabolic demand and experience significant light-induced oxidative stress due to their role in light transduction).

Because of their role in light transduction, photoreceptor death leads to blindness.

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WHY DOES THIS HAPPEN?

When we age, the level of NAD+ in our body decreases, leading to metabolic dysfunction and, eventually, photoreceptor death.

Retinal NAD+ (nicotinamide adenine dinucleotide)  deficiency is an age-related disease.

It consists of retinal dysfunction, including light-induced degeneration, and streptozotocin-induced diabetic retinopathy.

Identifying treatment strategies to prevent this disease is imperative.
NAD+  has been shown to be important in many biological processes, including metabolism,  circadian rhythms, and aging. This is because NAD+ is an essential coenzyme, functioning as an electron carrier in glycolysis and the Krebs cycle.
This studies demonstrates the importance of  NAD+ in neurodegeneration ( ).
In fact, NAD+ biosynthesis plays an important role in photoreceptor function and survival. 
Researchers identified that rode or cone photoreceptor-specific deletion of NAMPT (nicotinamide phosphoribosyltransferase), the rate-limiting enzyme in NAD+ synthesis, caused retinal degeneration. 
They studied the role of NAMPT-mediated NADbiosynthesis in photoreceptor survival and vision.
The results are impressive and show the importance of NAD+ in retinal degeneration and age-related retinal dysfunction.
This leads to the possibility of using NAD+ intermediates ( NMN, NR) to protect against retinal degeneration.
For more details and to read the full study, visit the link below:

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