NAD+ precursors such as NR and NMN, have been extensively studies over the past years due to their potential benefits on humans and animals.
Supplementing these NAD+ intermediates has shown preventive and therapeutic effects, ameliorating age-associated pathophysiologies and disease conditions.
In this study, researchers focused on the biology of NMN and NR, in an in vivo context.
These NAD+ precursors are found in a wide variety of our daily foods, such as vegetables, fruits, and meat (Mills et al., 2016).
Accumulating evidence suggests that NAD+ levels decline with age at a systemic level in diverse organisms, including rodents and humans, contributing to the development of many age-associated pathophysiologies (Canto et al., 2015; Imai and Guarente, 2014; Verdin, 2015).Therefore, there has been an increasing interest in using NAD+ intermediates as effective interventions to ameliorate or even prevent certain aspects of age-associated functional decline.