Recent results on a study on mice are a promising step towards mans search for the "elixir of life".
The study, conducted by Dr David Sinclair and colleagues from Harvard Medical School, identified that supplementation with NAD precursors can restore poor blood flow in mice.
So what is the importance of blood flow and aging?
Aging is associated with a decline in capillary density and blood flow.
A decrease of vascular function is one of the main causes of aging.
Sinclair and colleagues found a way to restore the blood in aging mice.
NMN (nicotinamide nucleotide) is a precursor of NAD+, and supplementation with such compound increases NAD+ levels in the body.
How does this affect blood flow?
Well, NAD+ plays an important part in the regulation of proteins called Sirtuins.
Surituins are important for a wide range of processes, including vascular maintenance.
Sirtuin 1 is expressed in endothelial cells of blood vessels i.e. the inner lining.
It was found that a loss of endothelial SIRT1 resulted in early decline in muscle vascular density exercise capacity, whilst an increase of SIRT1 actually had a protective effect.
So a decrease in endothelial NAD+, thus a decrease in SIRT1 expression, is one of the reasons why our ability to exercise declines as we age.
How can we benefit?
NMN supplementation in old mice actually restored the formation of new blood vessels.
The effects of aging on mouse microvasculature were actually easily reversed.
These significant findings are game changers when it comes to improving blood flow, increasing human performance and improving mobility in the elderly.
NMN may be the supplement for a happier, healthier and more mobile life.