Keto diet & NAD+ therapy - Cancer as a mitochondrial disease

What is the root cause of cancer?

Mutated genes are the root cause of cancer. In addition, toxins that mutate DNA (teratogens) are also considered a cause of cancer.

There are two main theories on the development of cancer.

According to the somatic mutation theory, cancer is considered a genetic disease. This theory is presented in most current college textbooks of genetics, biochemistry, and cell biology, and is the mainstay of the National Cancer Institute.

The somatic mutation theory states that:

Cancer is a genetic disease—that is, it is caused by changes to genes that control the way our cells function, especially how they grow and dividecancer.gov/cancertopics/what-is-cancer

However, emerging evidence suggests that cancer is a mitochondrial metabolic disease, as the original theory of Otto Warburg suggests (Warburg, 1956a,b; Burk et al., 1967).

The study in the link below, is consistent with the notion that cancer is primarily a mitochondrial metabolic disease.

ncbi.nlm.nih.gov/pmc/articles/PMC4493566/

It suggest that cancer originates from damage to the mitochondria rather than from damage to the genes in the nucleus.

This view is also consistent with the previous findings of Roskelley et al. (1943), Hu et al. (2012).

In the study, researchers described how the somatic mutations in tumors cells would reduce adaptability to stress, thus making the tumor cells vulnerable to elimination through “press-pulse” metabolic therapies involving non-toxic drugs and ketogenic diets (Seyfried and Mukherjee, 2005; Seyfried et al., 2014).

Thus, it is important to understand the role of the mitochondria in the origin, management, and prevention of the disease.

At this point it is logical to answer this question:

Are zero-carb diets an effective treatment for cancer?

The Ketogenic Diet (KD) has been explored as a potential therapy in diverse neurological disorders, yet no mechanisms of action have been established.

The diet’s high fat, low carbohydrate composition reduces glucose utilization and promotes the production of ketone bodies.

Those who are on Keto diet, have a more efficient energy source than glucose and an enhanced mitochondrial function and biogenesis.

At this point, it is inevitable mention the importance of NAD+, a marker for mitochondrial and cellular health. In fact, cellular energy production depends on NAD+.

NAD+, activates signaling pathways, including those involving sirtuin activity, thus increasing levels has benefits such as longevity and reduced inflammation.

Buy NAD+ here!

In the study provided in the link below, researchers propose that a Keto diet will increase the NAD+/NADH ratio.

When mice were fed the Keto Diet, significant increases in hippocampal NAD+/NADH ratio and blood ketone bodies were already detected at 2 days and remained elevated at 3 weeks, indicating an early and persistent metabolic shift. This initial data findings and other literature sources suggest that increased NAD during ketolytic metabolism may be a primary mechanism behind the beneficial effects of this metabolic therapy in a variety of brain disorders and in promoting health and longevity.

ncbi.nlm.nih.gov/pmc/articles/PMC5694488/

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