Increasing levels of NAD+ improves muscle function

The prevention of degenerative muscular conditions has been a hot topic for research in recent years.

Degeneration of muscle occurs in muscular dystrophies, myopathies and many other disease.

Muscle wasting is also inevitable as we age. As we get older, muscles lose mass and strength.

During the process, muscle cells lose mitochondria and the essential cofactor NAD+.

Scientists have discovered a potential way to treat a number of muscle-wasting diseases by repletion of NAD+.

See NAD+ products here!

NR Effect on Muscle Fiber 

The Study

Dr. Dongryeol Ryu and team studied mitochondria and NAD+ in a diverse population of normal healthy mice. [1]

The observed a correlation between amount of mRNA transcripts related to mitochondrial production  and NAD+ synthesis.

The findings indicate that NAD+ is essential for protecting muscle from degeneration.

Additional research was carried out on patients with Duchene’s Muscular Dystrophy (DMD).

DMD is a genetic disorder and symptoms include muscle weakness and degeneration.

It is caused by an absence of the protein dystrophin.

Dystrophin is a vital part of a protein complex that holds the muscle fibers together.

Mice with DMD were enriched with PARPs and NNMT, these enzymes are consumers of NAD+.

Significant reduction in NAD+ levels ere observed, as well as reduced expression of NAMPT, the enzyme involved in NAD+ biosynthesis.

NR was then supplemented, which restored NAD+, improving muscle function and heart pathology.

Conclusion

NAD+ restoration using NR supplementation improved muscle function.

This is due to an increase in mitochondria, an increase in muscle structural proteins and a decrease in inflammation.

Suggesting that NR supplementation may be a successful therapy for many muscle wasting diseases.

 

 

 

[1] stm.sciencemag.org/content/8/361/361ra139

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